1Department of Nutrition and Dietetics, Faculty of Health Science, Gazi University, Ankara, Turkey
2Celiac Disease Research Laboratory, Department of Pediatrics, Università Politecnica delle Marche, Ancona, Italy
*Corresponding author: Yeliz Serin, Department of Nutrition and Dietetics, Faculty of Health Science, Gazi University, Ankara, Turkey. Tel: +90 312 216 26 22; E-mail: dytyelizserin@gmail.com
Received: June 15, 2021; Accepted: July 06, 2021; Published: July 16, 2021
Celiac Disease (CD) is a multifactorial disorder occurs due to the indigestion of immune-potent gluten peptides found in wheat and related grains in genetically predisposed individuals. More than 1% of the world population is affected with CD. A life-long strict Gluten-Free Diet (GFD) is the only acceptable treatment for CD till date. Susceptibility to CD is inherited in the family members. Class-II Human Leukocyte Antigen (HLA) DQ alleles are strongly associated with CD susceptibility. High prevalence (up to 20 %) of CD in First-Degree Family members (FDRs) of CD patients has been reported. Due to this, CD affected individuals face a challenges for their marriage. There is a misconception in society that marrying a CD affected person will inherit the disease in their child. However, this is not always true, and it can be answered scientifically to some extent by genetic testing (HLA-DQ characterization).
So far no article has discussed this issue in detail. In this article, we raised this issue and provided scientific justifications. Our justifications are based on the previous documented information that investigated the family risk of CD. Our literature-based information concluded that except for some certain situations, marriage between a healthy individual (HLA-DQ negative) with a celiac affected individual will not inherit CD to their progeny. Hence, a healthy individual may decide to marry to a CD patient. There are only some probabilities that a celiac patient’s child would develop CD. However, there are certain preventive measures that CD parents should follow. Moreover, CD genetic test (HLA-DQ characterization) is very important to determine the risk of developing CD in the child.
Celiac Disease; Genetic; Gluten Free Diet; HLA-DQ Allele; Marriage
Citation: Serin Y, Verma AK (2021) Complications of Marriage of Celiac Individuals and Risk of Developing Celiac Disease in Their Progeny. J Nutri Sci Food 1: 002.
Copyright: © 2021 Serin Y, et al., This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
